This caused the OS to become visibly unstable and I was eventually logged out automatically. As a shot in the dark I killed coreservicesd. Inspired by answer, I started looking into other system daemon's that might do the trick if restarted. I'm not sure how the following solved the problem. Is there a way to force OS X to reload the device? Preferably some command line voodoo that I could fire off quickly when needed or wrap up in a nice little shell script. Most posts around the internet suggest updating the OS or the software/firmware for the device. I have had other m-audio interfaces that were automatically detected when connected, and I'm pretty sure this one should be the same. In order to get my macbook to recognize it (display in audio/midi setup), I have to reboot, which is a hassle. I have an external audio interface (M-audio fast track c400).